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USC-OGP 2-DE database
Two-dimensional polyacrylamide gel electrophoresis database
USC-OGP 2-DE database
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World-2DPAGE Portal
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Searching in 'USC-OGP 2-DE database' for entry
matching:
P52565
USC-OGP 2-DE database
:
P52565
P52565
General information about the entry
View entry in simple text format
Entry name
GDIR1_HUMAN
Primary accession number
P52565
integrated into USC-OGP 2-DE database on
January 17, 2017 (release 1)
2D Annotations were last modified on
January 17, 2017 (version 1)
General Annotations were last modified on
April 5, 2017 (version 2)
Name and origin of the protein
Description
RecName: Full=Rho GDP-dissociation inhibitor 1; Short=Rho GDI 1; AltName: Full=Rho-GDI alpha;.
Gene name
Name=ARHGDIA
Synonyms=GDIA1
Annotated species
Homo sapiens (Human) [TaxID:
9606
]
Taxonomy
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]
2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein
PLATELET_4-5
{PLATELET 4-5}
Homo sapiens (Human)
map experimental info
PLATELET_4-5
MAP LOCATIONS:
SPOT OGP-0188
:
pI=5.00; Mw=25675
SPOT OGP-0196
:
pI=5.00; Mw=25121
SPOT OGP-0198
:
pI=4.93; Mw=24929
UVEAL_MELANOMA_3-10
{UVEAL MELANOMA 3-10}
Homo sapiens (Human)
map experimental info
UVEAL_MELANOMA_3-10
MAP LOCATIONS:
SPOT OGP-1275
:
pI=5.05; Mw=27445
SPOT OGP-1278
:
pI=5.09; Mw=26938
Cross-references
UniProtKB/Swiss-Prot
P52565; GDIR1_HUMAN.
2D PAGE maps for identified proteins
How to interpret a protein map
You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
Warning 1
: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
Warning 2
: the 2D PAGE map is built on demand. This may take some few seconds to be computed.
External data extracted from
UniProtKB/Swiss-Prot
Extracted from
UniProtKB/Swiss-Prot
, release:
0.0
Entry name
GDIR1_HUMAN
Primary accession number
P52565
Secondary accession number(s)
A8MXW0 B2R5X1 B4DDD3 B4DUV9 Q6IBM5
Sequence was last modified on
January 23, 2007 (version 3)
Annotations were last modified on
February 15, 2017 (version 172)
Name and origin of the protein
Description
RecName: Full=Rho GDP-dissociation inhibitor 1; Short=Rho GDI 1; AltName: Full=Rho-GDI alpha;
Gene name
Name=ARHGDIA
Synonyms=GDIA1
Encoded on
Name=ARHGDIA; Synonyms=GDIA1
Keywords
3D-structure
;
Acetylation
;
Alternative splicing
;
Complete proteome
;
Cytoplasm
;
Direct protein sequencing
;
Disease mutation
;
GTPase activation
;
Isopeptide bond
;
Phosphoprotein
;
Reference proteome
;
Ubl conjugation
.
Copyright
Copyrighted by the UniProt Consortium, see
http://www.uniprot.org/help/license
. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBL
X69550; CAA49281.1
; -; mRNA
EMBL
D13989; BAA03096.1
; -; mRNA
EMBL
M97579; AAA36566.1
; -; mRNA
EMBL
X63863; CAA45344.1
; -; Genomic_DNA
EMBL
AK300816; BAG62471.1
; -; mRNA
EMBL
AK312347; BAG35268.1
; -; mRNA
EMBL
AF498926; AAM21074.1
; -; mRNA
EMBL
BT006884; AAP35530.1
; -; mRNA
EMBL
CR456777; CAG33058.1
; -; mRNA
EMBL
AC145207; -
; NOT_ANNOTATED_CDS; Genomic_DNA
EMBL
CH471099; EAW89697.1
; -; Genomic_DNA
EMBL
BC005851; AAH05851.1
; -; mRNA
EMBL
BC005875; AAH05875.1
; -; mRNA
EMBL
BC008701; AAH08701.1
; -; mRNA
EMBL
BC009759; AAH09759.1
; -; mRNA
EMBL
BC016031; AAH16031.1
; -; mRNA
EMBL
BC016185; AAH16185.1
; -; mRNA
EMBL
BC024258; AAH24258.1
; -; mRNA
EMBL
BC027730; AAH27730.1
; -; mRNA
EMBL
BC075827; AAH75827.1
; -; mRNA
EMBL
BC106044; AAI06045.1
; -; mRNA
CCDS
CCDS11788.1; -. [P52565-1]
; .
CCDS
CCDS58609.1; -. [P52565-2]
; .
PIR
I38156; I38156
; .
RefSeq
NP_001172006.1; NM_001185077.2. [P52565-1]
; .
RefSeq
NP_001172007.1; NM_001185078.2. [P52565-2]
; .
RefSeq
NP_001288169.1; NM_001301240.1
; .
RefSeq
NP_001288170.1; NM_001301241.1
; .
RefSeq
NP_001288171.1; NM_001301242.1
; .
RefSeq
NP_001288172.1; NM_001301243.1
; .
RefSeq
NP_004300.1; NM_004309.5. [P52565-1]
; .
UniGene
Hs.159161; -
; .
UniGene
Hs.599508; -
; .
UniGene
Hs.728006; -
; .
PDB
1CC0; X-ray
; 5.00 A; E/F=1-204
PDB
1FSO; X-ray
; 2.00 A; A=67-204
PDB
1FST; X-ray
; 2.70 A; A/B=24-204
PDB
1FT0; X-ray
; 2.60 A; A/B=67-204
PDB
1FT3; X-ray
; 2.80 A; A/B=67-204
PDB
1HH4; X-ray
; 2.70 A; D/E=1-204
PDB
1KMT; X-ray
; 1.30 A; A/B=67-204
PDB
1QVY; X-ray
; 1.60 A; A/B/C/D=67-204
PDB
1RHO; X-ray
; 2.50 A; A/B/C=59-203
PDB
2BXW; X-ray
; 2.40 A; A/B=67-204
PDB
2JHS; X-ray
; 1.95 A; A=67-202
PDB
2JHT; X-ray
; 1.88 A; A/B/C/D=67-202
PDB
2JHU; X-ray
; 1.65 A; A/B=67-202
PDB
2JHV; X-ray
; 2.07 A; A/B/C/D/E/F=67-202
PDB
2JHW; X-ray
; 2.50 A; A/B=67-202
PDB
2JHX; X-ray
; 1.60 A; A/B=67-202
PDB
2JHY; X-ray
; 1.90 A; A=67-202
PDB
2JHZ; X-ray
; 2.20 A; A/B=67-202
PDB
2JI0; X-ray
; 2.10 A; A=67-202
PDB
2N80; NMR
; -; B=31-204
PDBsum
1CC0; -
; .
PDBsum
1FSO; -
; .
PDBsum
1FST; -
; .
PDBsum
1FT0; -
; .
PDBsum
1FT3; -
; .
PDBsum
1HH4; -
; .
PDBsum
1KMT; -
; .
PDBsum
1QVY; -
; .
PDBsum
1RHO; -
; .
PDBsum
2BXW; -
; .
PDBsum
2JHS; -
; .
PDBsum
2JHT; -
; .
PDBsum
2JHU; -
; .
PDBsum
2JHV; -
; .
PDBsum
2JHW; -
; .
PDBsum
2JHX; -
; .
PDBsum
2JHY; -
; .
PDBsum
2JHZ; -
; .
PDBsum
2JI0; -
; .
PDBsum
2N80; -
; .
ProteinModelPortal
P52565; -
; .
SMR
P52565; -
; .
BioGrid
106889; 91
; .
IntAct
P52565; 38
; .
MINT
MINT-93856; -
; .
STRING
9606.ENSP00000269321; -
; .
BindingDB
P52565; -
; .
ChEMBL
CHEMBL3638327; -
; .
iPTMnet
P52565; -
; .
PhosphoSitePlus
P52565; -
; .
SwissPalm
P52565; -
; .
BioMuta
ARHGDIA; -
; .
DMDM
1707892; -
; .
DOSAC-COBS-2DPAGE
P52565; -
; .
OGP
P52565; -
; .
REPRODUCTION-2DPAGE
IPI00003815; -
; .
EPD
P52565; -
; .
PaxDb
P52565; -
; .
PeptideAtlas
P52565; -
; .
PRIDE
P52565; -
; .
TopDownProteomics
P52565-1; -. [P52565-1]
; .
DNASU
396; -
; .
Ensembl
ENST00000269321; ENSP00000269321
; ENSG00000141522. [P52565-1]; .
Ensembl
ENST00000400721; ENSP00000383556
; ENSG00000141522. [P52565-2]; .
Ensembl
ENST00000541078; ENSP00000441348
; ENSG00000141522. [P52565-1]; .
Ensembl
ENST00000580685; ENSP00000464205
; ENSG00000141522. [P52565-1]; .
GeneID
396; -
; .
KEGG
hsa:396; -
; .
UCSC
uc021ufg.2; human. [P52565-1]
; .
CTD
396; -
; .
DisGeNET
396; -
; .
GeneCards
ARHGDIA; -
; .
HGNC
HGNC:678; ARHGDIA
; .
HPA
CAB010005; -
; .
HPA
HPA021407; -
; .
MalaCards
ARHGDIA; -
; .
MIM
601925; gene
; .
MIM
615244; phenotype
; .
neXtProt
NX_P52565; -
; .
OpenTargets
ENSG00000141522; -
; .
Orphanet
93217; Familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis
; .
PharmGKB
PA24963; -
; .
eggNOG
KOG3205; Eukaryota
; .
eggNOG
ENOG4111K44; LUCA
; .
GeneTree
ENSGT00390000006233; -
; .
HOGENOM
HOG000175765; -
; .
HOVERGEN
HBG000206; -
; .
InParanoid
P52565; -
; .
KO
K12462; -
; .
OMA
QMSESSI; -
; .
PhylomeDB
P52565; -
; .
TreeFam
TF105387; -
; .
Reactome
R-HSA-193634; Axonal growth inhibition (RHOA activation)
; .
Reactome
R-HSA-194840; Rho GTPase cycle
; .
Reactome
R-HSA-209563; Axonal growth stimulation
; .
SIGNOR
P52565; -
; .
EvolutionaryTrace
P52565; -
; .
GeneWiki
ARHGDIA; -
; .
GenomeRNAi
396; -
; .
PRO
PR:P52565; -
; .
Proteomes
UP000005640; Chromosome 17
; .
Bgee
ENSG00000141522; -
; .
CleanEx
HS_ARHGDIA; -
; .
ExpressionAtlas
P52565; baseline and differential
; .
Genevisible
P52565; HS
; .
GO
GO:0005856; C:cytoskeleton
; TAS:UniProtKB; .
GO
GO:0005829; C:cytosol
; TAS:Reactome; .
GO
GO:0070062; C:extracellular exosome
; IDA:UniProtKB; .
GO
GO:0005096; F:GTPase activator activity
; IEA:UniProtKB-KW; .
GO
GO:0005094; F:Rho GDP-dissociation inhibitor activity
; TAS:ProtInc; .
GO
GO:0006928; P:movement of cell or subcellular component
; TAS:UniProtKB; .
GO
GO:0043066; P:negative regulation of apoptotic process
; TAS:UniProtKB; .
GO
GO:0050771; P:negative regulation of axonogenesis
; TAS:Reactome; .
GO
GO:0007162; P:negative regulation of cell adhesion
; TAS:ProtInc; .
GO
GO:0050772; P:positive regulation of axonogenesis
; TAS:Reactome; .
GO
GO:2000249; P:regulation of actin cytoskeleton reorganization
; IMP:UniProtKB; .
GO
GO:0035023; P:regulation of Rho protein signal transduction
; IMP:UniProtKB; .
GO
GO:0051056; P:regulation of small GTPase mediated signal transduction
; TAS:Reactome; .
GO
GO:0071526; P:semaphorin-plexin signaling pathway
; ISS:UniProtKB; .
Gene3D
2.70.50.30; -
; 1; .
InterPro
IPR014756; Ig_E-set
; .
InterPro
IPR000406; Rho_GDI
; .
InterPro
IPR024792; RhoGDI_domain
; .
PANTHER
PTHR10980; PTHR10980
; 1; .
Pfam
PF02115; Rho_GDI
; 1; .
PRINTS
PR00492; RHOGDI
; .
SUPFAM
SSF81296; SSF81296
; 1; .
Gateways to other related servers
The World-2DPAGE Constellation
- Entry point to the world-wide 2-DPAGE resources.
World-2DPAGE Repository
- A public repository for gel-based proteomics data linked to protein identification published in the literature.
World-2DPAGE Portal
- A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
SWISS-2DPAGE
- The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
ExPASy
- The resources web server of the
Swiss Institute of Bioinformatics
Database constructed and maintained by
Angel Garcia
, using the
Make2D-DB II
package (
ver. 3.10.2
) from the
World-2DPAGE Constellation
of the
ExPASy web server
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